Detrol is just one of the medications that has been added to the Food and Drug Administration (FDA) quarterly report on treatments identified as a potential safety risk to patients. According to the report, Detrol, also known as Tolterodine Tartrate, is being evaluated by the agency after reports of patients diagnosed with Stevens Johnson Syndrome (SJS), a rare but life-threatening skin condition, after taking the medication.

SJS and its most severe form, toxic epidermal necrolysis (TEN), are severe adverse reactions to medications. More than 200 medications have been linked to the condition. Those who suffer from SJS or TEN experience rashes that blister over and cause the skin to peel off in sheets. Blisters can also form on the eyes, inside the mouth and on internal organs, causing ocular problems, dehydration, infection and sometimes death.

Other medications listed in the FDA’s quarterly report and investigated for a possible link to skin reactions include hydrochlorothiazide in combination with other products, sleep disorder medications modafinil (Provigil) and Armodafinil (Nuvigil), and smoking cessation drug Chantix.

The FDA reports that it is continuing to evaluate these issues to determine if there is need for regulatory action. In the interim, the FDA emphasizes that the listing of a drug and a potential safety issue does not mean that the medicines should not be prescribed nor that patients taking those drugs should stop taking the medication. Patients with questions about their medication should contact their health care provider.

Source: FDA

SOURCE: Stevens Johnson Syndrome › New drugs investigated for possible skin reactions

Common side effects of Tamiflu and Relenza include dizziness, vomiting and diarrhea. Other, more serious adverse reactions are rare but can occur, including Stevens Johnson Syndrome, or SJS. SJS is a rare reaction to medication that begins with rashes on the skin that blister over, causing the skin to peel off in sheets. Blisters also can form on the eyes and mouth, which can lead to ocular problems, dehydration, infection and, in severe cases, death.

In Hong Kong in particular, pharmacists are urging the public not to stock up on the antiviral medications, as they say the Chinese government has plenty of the medicines in stock to combat a pandemic should one arise. The urgings come just six years after the deadly SARS virus struck that nation. About 400 Chinese pharmacies – or 95 percent of the market – have joined a campaign to keep residents’ fears at bay. There have been no swine flu cases reported in Hong Kong to date.

“The pharmacies will advise individuals whether the symptoms they have reflect a cold or something more serious such as flu,” head of Pharmacovigilance Kevin Cheung Kin-man told The Standard. “If the symptoms persist for days, people will be advised to consult a doctor. In the meantime, in the case of colds, pharmacists will be able to recommend appropriate over-the- counter medication.”

SOURCE: Stevens Johnson Syndrome › Pharmacists warn against use of anti-virals amid swine flu scare

As a young child, Lisa contracted pneumonia and spent a month in the hospital. She grew up with an abusive stepmother and struggled through a difficult marriage. Despite the obstacles, she managed to raise two children and find a career in real estate. But last week, the young woman with an infectious personality, hit another road block. She was diagnosed with Stevens Johnson Syndrome (SJS), an adverse reaction to antibiotics prescribed to her following minor surgery.

SJS is a rare but life-threatening hypersensitivity disorder that presents with a rash on the skin. As the condition progresses, the rash blisters over and the skin begins to peel off in sheets. This causes great pain and makes the body prone to infection. Most patients are treated in burn units. The mucus membranes also can be affected, causing blisters to form in the mouth and on the eyes. Dehydration and ocular problems become serious side effects. Severe cases of SJS can be fatal.

More than 200 medications have been linked to SJS or its most severe form, toxic epidermal necrylosis (TEN), most commonly antibiotics, ibuprofen and anti-seizure medication. SJS and TEN doesn’t discriminate based on age or gender. The warnings on the medications’ label often go unnoticed. And the condition is so rare that it can be hard to diagnose.

Some organizations, such as the Stevens Johnson Syndrome Foundation seek to raise awareness and “provide information about adverse allergic drug reactions so a quick diagnosis can be made and the offending drug stopped as soon as possible.”

When Mark visited his sister Lisa, she was covered from head to toe with blisters and rashes. Despite her condition, she seems brave. “That’s why she’s my hero,” Mark says.

Mark Cripps is Managing Editor for the Dundas Star News, the Ontario, Canada newspaper where he shared the story of his sister.

SOURCE: Stevens Johnson Syndrome › Newspaper managing editor calls sister with SJS a hero

SJS is a rare but life-threatening disorder usually caused by an adverse reaction to common medication such as antibiotics, anti-seizure medication and ibuprofen. SJS is a hypersensitivity disorder that presents with a rash on the skin that blisters over causing the skin to peel off in sheets. Mucus membranes also can be affected, with blisters developing on the eyes and in the mouth which can lead to ocular problems, dehydration, infection and even death.

Rachel’s videos show her gradual physical progress. What we see is that surviving the condition is the first hurdle. The next is the physical recovery – as the skin heals and the hair grows back. The emotional recovery can take longer, and Rachel shares that promise and pain in her last two videos from February 2, and April 9.

Rachel tells us that she feels physically stronger every day. She is in therapy now to deal with the depression that makes her “fight the urge every day not to cry.” She has noticed those closest to her drift away or change the way they treat her. One blessing is a friend she has found who suffered from SJS five years ago. The friend shared a picture of herself – completely physically healed from the peeled-off skin and hairlessness. It gives Rachel hope that she, too, will look like her old self again.

Her video testimonials are honest and real, and not only serve as a healing mechanism for her, but a way for her to help others. The videos, she says, “may benefit somebody in the future.”

SOURCE: Stevens Johnson Syndrome › SpunkyRachel discusses physical, emotional healing from SJS

The eyes are especially vulnerable. Typical ocular problems associated with SJS and TEN can include conjunctivitis, scarring of the conjunctiva, inflammation inside the eye (iritis), corneal blisters and perforation, which can potentially lead to permanent vision loss. Therapy for ocular problems often includes ocular lubrication with artificial tears and ointments. Plus, individuals must be on constant watch for various ocular infections. Corneal transplants, limbal stem cell transplantations or artificial corneal procedures maybe considered if there is lasting damage.

One company is helping ease the sting of recovery for people who have had SJS and TEN and stuffer from lingering eye problems. Eyeeco, a distributor of eye hydration products, offers 15 percent discounts on its products to those who have had SJS or TEN. All users need to do is type “SJS” in the promotional code field and their discount will show up at checkout. Eyeeco’s Tranquileyes eye hydrating therapy, which includes drops and goggles, is specially designed to naturally hydrate dry, tired eyes, reduce eye puffiness and create complete darkness to enhance relaxation and sleep. Chronic Dry Eye Kits cost between $49 and $59.

SOURCE: Stevens Johnson Syndrome › Company offers discount on eye products to SJS/TEN survivors